性别

男

电话

通讯地址

贵州省遵义市新蒲新区学府西路6号（新蒲校区）

邮编

563000

邮箱

bozhang0509@sina.com

职称

副教授

职务

简介

张博，博士，副教授，硕士生导师，2008年在法国居里夫人研究所学习3年，2016年毕业于西北农林科技大学生命学院国家旱区重点实验室。2017年入职遵义医学院，同年加入中国农工民主党，2020年任职中国农工民主党遵义医科大学二支部主委，2021年入选遵义市第六届政协委员。获评中国农工民主党贵州省基层组织工作先进个人，省级社情民意突出贡献奖；中国农工民主党遵义市党务工作先进个人。贵州省教育厅科技拔尖人才，必威学科骨干，南山班导师，目前主持国家自然科学基金一项，省级项目3项，地厅级1项。在NUCLEIC ACIDS RESEARCH，EMBO JOURNAL，JOURNAL OF BIOLOGICAL CHEMISTRY，PHYSICAL REVIEW LETTERS等杂志上发表SCI收录论文共16篇，其中第一作者发表最高影响因子19.16。

教育背景

理学博士生物化学与分子生物学专业

学术组织任职

中国研究型医院学会临床数据与样本资源库专业委员会委员

主讲课程

生物化学与分子生物学

科研项目

1.国家自然科学基金，31860315，40万元、主持。

2.贵州省科技厅“新型冠状病毒”专项支撑计划，黔科合基础[2020]4Y204，40万元、主持。

3.贵州省普通高等学校科技拔尖人才项目，黔教合KY字[2021]035，30万元、主持。

4.贵州省科技计划项目，黔科合基础[2020]1Y151，10万元、主持。

5.贵州省卫生健康委科学项目，黔卫健函〔2020〕170号，4万元、主持。

6.遵义医学院高级人才科研启动资金项目，F-939，10万元、主持。

发表论文

1.Zhang, Bo†, Wen-Qiang Wu†,, Na-Nv Liu, Xiao-Lei Duan, Ming Li, Shuo-Xing Dou and Xu-Guang Xi,3*. G-quadruplex and G-rich sequence stimulate Pif1p-catalyzed downstream duplex DNA unwinding through reducing waiting time at ss/dsDNA junction. Nucleic Acids Research 2016 July；Vol. 44, No. 17 8385–8394.(IF: 19.16 )

2.Bo Zhang1*†,Qintao Zhang1†,Xinting Zhu1,Dayu Li1,Xiaolei Duan2,Jiao Jin1,Kejia Wang3,Yan Xie4* andYang Liu4*. Mechanistic Insight Into Cadmium- and Zinc-Induced Inactivation of the Candida albicans Pif1 Helicase. Front. Mol. Biosci. 21 January 2022doi.org/10.3389/fmolb.2021.778647.(IF:6.113)

3.Bo Zhang1^*†, Yan Xie2^†, Zhaoling Lan^1†, Dayu Li¹, Junjie Tian¹, Qintao Zhang¹, Hongji Tian¹, Jiali Yang¹, Xinnan Zhou¹, Shuyi Qiu³, Keyu Lu^1*and Yang Liu^2,3*.. SARS-CoV-2 Nucleocapsid Protein Has DNA-Melting and Strand-Annealing Activities With Different Properties From SARS-CoV-2 Nsp13.Front. Microbiol., 22 July 2022.doi.org/10.3389/fmicb.2022.851202.(IF:6.064)

4.Bo Zhang1^{* †},Junjie Tian1^†,Qintao Zhang^1†, Yan Xie², Kejia Wang³, Shuyi Qiu³, Keyu Lu¹* and Yang Liu^{2,3 *}Comparing the Nucleocapsid Proteins of Human Coronaviruses: Structure, Immunoregulation, Vaccine, and Targeted Drug.Front Mol Biosci. 2022;9.10.3389/fmolb.2022.761173.(IF:6.113)

5.Zhang B, Zhang AH, Chen L, Xi XG. Inhibition of DNA helicase, ATPase and DNA-binding activities of E. coli RecQ helicase by chemotherapeutic agents. J Biochem; 2008 Feb ;143(6):773-9.(IF:3.241)

6.Yang Liu1,2,3,4,Xinting Zhu2,Kejia Wang1,3,4,Bo Zhang2*andShuyi Qiu1,3,4*. The Cellular Functions and Molecular Mechanisms of G-Quadruplex Unwinding Helicases in Humans. Front. Mol. Biosci. 29 November 2021doi.org/10.3389/fmolb.2021.783889.(IF:6.113)

7.Xiao-Bin,Wei†,Bo Zhang†, Na-Nv Liu1, Brigitte Rene, Olivier Mauffret and Xu-Guang Xi. A 3’-5’ exonuclease activity embedded in the helicase core domain of C. Albicans Pif1 helicase. Scientific Report；2017 February 7:42865 (co-first author).(IF:4.996)

8.Jing Zhao†,Bo Zhang†, Junpeng Jiang, Nanv Liu, Qi Wei, Xuguang Xi and Jing Fu* AvrXa27 binding influences unwinding of the double-stranded DNA in the UPT box Biochemical and Biophysical Research Communications; 2017 January; 484 (2017) 390e395 26 (co-first author).(IF:3.322)

9.Xuexiang Lin1^2,3, XiaoYu Liu^3,4,Bo Zhang³, AiQing Qin³, KwokMin Hui3 , Kevin Shi3 , Yang Liu3 , DonGabriel3 & X. James Li3. A rapid infuenza diagnostic test based on detection of viral neuraminidase activity. Scientifc Reports (2022)12:505 41598-021-04538-4(IF:4.996)

10.Wenxia Lin, 1,4 Jianbing Ma, 1,4 Daguan Nong, 1,4 Chunhua Xu, 1,4Bo Zhang, 2 Jinghua Li, 1 Qi Jia, 1,4 Shuoxing Dou, 1,4，Fangfu Ye, 1,4 Xuguang Xi, 2,3 Ying Lu, 1,4,* and Ming Li 1,4,†Helicase Stepping Investigated with One-Nucleotide Resolution Fluorescence Resonance Energy Transfer PHYSICAL REVIEW LETTERS 29 SEP 2017 PRL 119, 138102 (2017).

11.Jing-Shi, Wei-Fei Chen,Bo-Zhang, Stephane Rety, and Xu-Guang Xi. A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation.Journal of biological chemistry(JBC) 2017 Apr 7;292(14):5909-5920.

12.Wen-Qiang Wu , Xi-Miao Hou ,Bo Zhang, Philippe Fossé , Brigitte René , Olivier Mauffret , Ming Li , Shuo-Xing Dou and Xu-Guang Xi. Single-molecule studies reveal reciprocating of WRN helicase core along ssDNA during DNA unwinding. Scientific Report；2017 February 7:43954.

13.Wei Qin,Nicolas Bazeille ,Etienne Henry,Bo Zhang, Eric Deprez Xu-Guang. Mechanistic insight into cadmium induced inactivation of the Bloom protein. Scientific Report; 2016 May; 6:26225.

14.Li, Jing-Hua; Lin, Wen-Xia;Zhang, Bo; Nong, Da-Guan; Ju, Hai-Peng; Ma, Jian-Bing; Xu, Chun-Hua; Ye, Fang-Fu; Xi, Xu-Guang; Li, Ming.; Lu, Ying; Dou, Shuo-Xing. Pif1 is a force-regulated helicase. Nucleic Acids Research ;2016 Apr Vol. 44, No. 9 4330–4339.

15.Sun B, Wei KJ,Zhang B, Zhang XH, Dou SX, Li M, Xi XG. Impediment of E. coli UvrD by DNA-destabilizing force reveals a strained-inchworm mechanism of DNA unwinding. EMBO J; 2008 Dec; 17;27(24):3279-87.

16.Guo RB, Rigolet P, Ren H,Zhang B, Zhang XD, Dou SX, Wang PY, Amor-Gueret M, Xi XG. Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein. Nucleic Acids Res. 2007 Sep;35(18):6297-310.

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